中文New Coronavirus Variant Strain 501Y-V2 yekuSouth Africa
Musi waZvita 18, 2020, South Africa yakaona 501Y-V2 mutant yekoronavirus nyowani.Iye zvino mutant wekuSouth Africa wapararira kunyika dzinopfuura makumi maviri.Ongororo dzakaratidza kuti pamusoro peNew Corona-virus Mutants inogona kutakura mamwe maNew Coronavirus akasiyana eK417N/T, E484K uye N501Y shanduko inogona kudzikisa kugona kwekudzivirira-induced plasma neutralizing antibodies.Zvakadaro, zvichienzaniswa nereference genome Wuh01 (sequence number MN908947), iyo 501Y.V2 yeSouth African mutant genome sequence ine 23 nucleotide akasiyana.Iine N501Y mutation yakafanana neBritain mutant B.1.1.7 sub-type, asi ichiri nekuchinja panzvimbo mbiri dzakakosha E484K uye K417N yeS protein ine zvingangove zvakakosha pakukwanisa kwehutachiona.
Iyo New Coronavirus iRNA-yakasungwa-imwechete, iyo Genome shanduko dzinowanzoitika.Kuonekwa kwechinangwa chimwe chete kunogona kutungamirira nyore nyore kutadza kuonekwa kwemasampuli ane low viral load uye mutated virus strains.Chiyero chekuongororazve mune imwe chete yakanaka mukuonekwa kwechinangwa, inogona kusvika kudarika 10%, iyo inogona kuwedzera basa uye kuwedzera nguva yekuongorora.Multi-target yekuona uye kuwirirana kwemigumisiro yechinangwa chimwe nechimwe kunogona kuwedzera chiyero chekuona uye kufambisa kuongororwa kwekutanga.
Mufananidzo 1. Schematic diagram yeNew Coronavirus infection mechanism
New Coronavirus Mutant B.1.1.7 wekuBritain
Musi wa26 Zvita 2020, bepa rekutanga resainzi reB.1.1.7 Strain rakatsikiswa pamhepo.The Institute of Hygiene University yeLondon UK neTropical Diseases, yakasimbisa kuti B.1.1.7 Strain inokwanisa kupararira kupfuura mamwe marudzi, ayo akanga anopfuura 56% (95% CI 50-74%).Nekuti iyi nyowani mutant strain ine simba rekutapurirana riri pachena, zvave kunetsa kudzora COVID-19.Mangwana acho, Yunivhesiti yeBirmingham kuUnited Kingdom yakaisa chinyorwa paMedRxiv.Chidzidzo chacho chakawana kuti nhamba yeORF1ab uye N virus gene makopi muvarwere vane hutachiona hweB.1.1.7 mutant strain (S-gene dropout) yakawedzera zvakanyanya;chiitiko ichi chakatariswa muhuwandu hwevanhu.Ichi chinyorwa chinoratidza kuti varwere vane utachiona hweB.1.1.7 hweBritain vane huwandu hwehutachiwana hwepamusoro, saka kuchinja uku kunogonawo kuva nehutachiona.
Mufananidzo 2. Iyo genome mutation kutevedzana kuri muiyo coronavirus mutant strain B.1.1.7 yekuBritain.
Mufananidzo 3. N501Y shanduko yakaitika muBritain neSouth AfricaVariants
Detection Kit yeNew Coronavirus Variants
Chuangkun Biotech Inc. yakabudirira kugadzira kit yekuona yeB.1.1.7 uye 501Y-V2 itsva coronavirus akasiyana.
Zvakanakira chigadzirwa ichi: kunzwisiswa kwepamusoro, kuona panguva imwe chete yezvinangwa zvina, kuvhara nzvimbo huru dzekuchinja kweB.1.1.7 mutant strain uye 501Y.V2 South African mutant strain.Iyi kit inogona kuona panguva imwe chete iyo N501Y, HV69-70del, E484K shanduko masaiti uye itsva coronavirus S gene;Kurumidza bvunzo: zvinongotora 1 awa 30 maminetsi kubva kumuenzaniso muunganidzwa kusvika pamhedzisiro.
Mufananidzo 4. Kuonekwa kweCOVID-19 Britain Variant Amplification Curve
Mufananidzo 5. Kuonekwa kweCOVID-19 South African Variant Amplification Curve
Mufananidzo 6. Wild-mhando yeNew coronavirus amplification curve
Hazvisi pachena kuti shanduko idzi dzinounganidza sei hutsva hwenguva refu yedenda reCOVID-19 kurudyi.Asi izvi zvinotiyeuchidza kuti shanduko idzi dzinogona kukanganisa kushanda kwekudzivirirwa kwechisikigo uye kusadzivirirwa kunounzwa nejekiseni.Izvo zvakare zvinotiyeuchidza kuti isu tinofanirwa kuramba tichitarisa iyo coronavirus nyowani kwenguva yakareba uye kugadzirisa iyo COVID-19 yekudzivirira kubata nekushanduka kweiyo coronavirus itsva.
Nguva yekutumira: Mar-12-2021